Bronx, New York 10467


To determine the efficacy of IV acetaminophen as an analgesic adjunct to IV hydromorphone in the treatment of acute severe pain in the elderly ED patients.

Study summary:

A randomized controlled trial to determine the efficacy of 1 gram IV acetaminophen as an analgesic adjunct to 0.5 mg IV hydromorphone in the treatment of acute severe pain in the elderly ED patients.


Inclusion Criteria: - Acute (less than 1 week in duration) severe pain necessitating use of IV opioids in the judgement of the treating attending physician Exclusion Criteria: - Use of other opioids or tramadol within past 24 hours: to avoid introducing assembly bias related to recent opioid use, since this may affect baseline levels of pain and need for analgesics. - Prior adverse reaction to hydromorphone, morphine, or acetaminophen. - Chronic pain syndrome: frequently recurrent or daily pain for at least 3 months results in modulation of pain perception which is thought to be due to down-regulation of pain receptors. Examples of chronic pain syndromes include sickle cell anemia, osteoarthritis, fibromyalgia, and peripheral neuropathies. - Alcohol intoxication: the presence of alcohol intoxication as judged by the treating physician may alter pain perception. - SBP <100 mm Hg: Opioids can produce peripheral vasodilation that may result in orthostatic hypotension. - HR < 60/min: Opioids can cause bradycardia. - Oxygen saturation < 95% on room air: For this study, oxygen saturation must be 95% or above on room air in order to be enrolled. - Use of MAO inhibitors in past 30 days: MAO inhibitors have been reported to intensify the effects of at least one opioid drug causing anxiety, confusion and significant respiratory depression or coma. - Patients using transdermal pain patches



Primary Contact:


Backup Contact:


Location Contact:

Bronx, New York 10467
United States

Andrew Chang, MD, MS
Phone: 718-920-6626

Site Status: Recruiting

Data Source:

Date Processed: January 21, 2020

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