Saint Louis, Missouri 63110

  • Parkinsons

Purpose:

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.


Study summary:

The purpose of this study is to use a brain imaging method called PIB PET and VAT PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. The investigators will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.


Criteria:

Inclusion Criteria: - PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry. Exclusion Criteria: - history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia. - severe systemic diseases. - inability to lie still for 90 minutes. - metallic implants, pacemakers, or any other contraindication to MRI. - refusal to consent to brain donation.


NCT ID:

NCT02763683


Primary Contact:

Principal Investigator
Joel S Perlmutter, MD
Washington University School of Medicine

Andrea Slavik, RN, BSN
Phone: 3145807553
Email: andreaslavik@wustl.edu


Backup Contact:

Email: enidmcintosh@wustl.edu
Enid McIntosh
Phone: 314-362-6026


Location Contact:

Saint Louis, Missouri 63110
United States

Kelly McVey, BSN
Phone: 314-362-0420
Email: mcveyk@wustl.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: July 30, 2021

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