Orange, California 92868

  • Kidney Diseases, Chronic

Purpose:

Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine complication of chronic kidney disease that has been associated with impaired quality of life and cardiovascular complications. While levothyroxine is one of the most frequently prescribed medications in chronic kidney disease patients, little is known about its efficacy and safety in this population. This study will investigate 1) whether levothyroxine adequately lowers thyrotropin (TSH) levels to therapeutic target ranges, and 2) if thyroid hormone replacement improves quality of life and cardiovascular markers, without leading to wasting in dialysis patients.


Criteria:

Inclusion Criteria: - Prevalent hemodialysis patients, elevated thyrotropin level, normal free thyroxine level. Exclusion Criteria: - Hyperthyroidism, active treatment with thyroid hormone replacement, prior thyroid malignancy, active pregnancy, active coronary ischemia or atrial fibrillation, osteoporosis, inability to provide consent without a proxy.


NCT ID:

NCT03191188


Primary Contact:

Principal Investigator
Connie M. Rhee, MD, MSc
University of California, Irvine

Connie M. Rhee, MD, MSc
Phone: 714-456-5142
Email: crhee1@uci.edu


Backup Contact:

N/A


Location Contact:

Orange, California 92868
United States

Kamyar Kalantar-Zadeh, MD, MPH, PhD
Phone: 714-634-3583
Email: kkz@uci.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: September 18, 2021

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.