Grand Forks, North Dakota 58203

  • Obesity


The purpose of this study is to determine the effects of daily protein intake patterns on body composition and eating behaviors during weight loss.

Study summary:

The reinforcing value of food varies greatly among individuals, but is strongest for those who are overweight or obese. Reducing energy intake, which is necessary for overweight and obese individuals to achieve a healthier body weight, increases the reinforcing value of food - especially for energy-dense snack foods. Food is a powerful reinforcer and is associated with energy intake; making it a primary contributing factor to an individual's weight loss struggle. Developing a way to decrease or limit the increase in food reinforcement during energy deficits would have important clinical impact. High-protein diets are known to be efficacious for weight loss and recently have been shown to decrease stimulation of the reward areas of the brain that stimulate reward-driven eating behavior. Nonetheless, sustaining a high-protein diet can be difficult, especially for women. Consuming a modest amount of protein at each meal may be better tolerated. However, we do not know whether this pattern of protein intake can assist women in staying "on track" with weight loss goals. This study will help begin to elucidate the connections between the daily pattern of protein intake on diet adherence, alterations in food reinforcement, and favorable body composition changes during weight loss.


Inclusion Criteria: - BMI 28-45 kg/m2 Exclusion Criteria: - unable or unwilling to consume animal products - unable or unwilling to attend treatment group meetings - had more than a 10% change in body weight in the 2 months prior to study start date - consuming a specialized diet - have a history of and eating or gastrointestinal disorder - currently or planning on becoming pregnant during the study timeline - lactating - have an uncontrolled metabolic illness/disease (fasting glucose >125 mg/dL) - have uncontrolled hypertension (>160/99 mm Hg) - have cancer or in short-term remission (less than 3 years) - have an infectious disease - suffer from alcohol or drug abuse - use tobacco and/or e-cigarette products on a regular basis - taking medications known to affect energy expenditure and appetite



Primary Contact:

Principal Investigator
Shanon Casperson, PhD
USDA Grand Forks Human Nutrition Research Center

Shanon Casperson, PhD
Phone: 701-795-8497

Backup Contact:


Location Contact:

Grand Forks, North Dakota 58203
United States

Angela J Scheett, MPH, RD
Phone: 701-795-8386

Site Status: Recruiting

Data Source:

Date Processed: August 04, 2021

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.