Stanford, California 94304

  • Chronic Migraine


Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal fluid, blood products, genetics, and patient phenotypes that might help explain this process.

Study summary:

The purpose of our study is to better understand disease processes and risk factors involved in onset of chronic daily headaches/Chronic Migraines. Further, The Investigators hopes to learn more about the etiology and disease mechanisms to optimize treatment strategies and determine prophylactic measures. Participation in this research study, will include online questionnaires, a blood sample, a lumbar puncture, and a magnetic resonance imaging (MRI) scan without contrast to measure brain activity. Participant may select to participate in a magnetic resonance imaging (MRI) scan and/ or lumbar puncture. participating in atleast 3 procedures is required (blood draw, online questionnaires , MRI and/or Spinal Tap. The study recruits participants with headache ( any type of headaches), and patients with no headaches ( or less than 2/year). Participants do not need to have a specified headache type. All participants are asked to complete an on-line survey to characterize a number of phenotypic features felt to be relevant by the Investigators. Three independent study groups (imaging, proteomics/genetics, and phenotyping) analyze data independently and stratify the data. Then, by group analysis, correlation among the different modalities is sought to identify features that distinguish common elements that might help elucidate features that could predict which patients with episodic headache are likely to progress to chronic, and which patients without headache might be at greater risk to develop new daily persistent headache.


Inclusion Criteria: - Subjects must agree to sign informed consent. - Subject must be able to or at least with some help willing to complete online questionnaires in English . - Willing to comply with study instructions. Exclusion Criteria: * Understand English.



Primary Contact:

Principal Investigator
Robert Cowan, MD, FAAN
Stanford University

Bharati Sanjanwala, M.Sc.
Phone: 650-721-2830

Backup Contact:

Anthony Bet, B.S.
Phone: 650-683-5823

Location Contact:

Stanford, California 94304
United States

Bharati Sanjanwala, M.Sc.
Phone: 650-721-2830

Site Status: Recruiting

Data Source:

Date Processed: September 28, 2021

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