Fargo, North Dakota 58103

  • Mild Cognitive Impairment

Purpose:

The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left dorsolateral prefrontal cortex (LDLPFC) will induce long-lasting effects in improving cognitive function and reducing cognitive fatigue and fatigability in PD patients with MCI.


Study summary:

Parkinson's disease (PD) is the second most common neurodegenerative disease (after Alzheimer's disease) and affects approximately one million people in the United States. Mild Cognitive Impairment (MCI) is very common even in early stages of PD. In addition to cognitive impairment, patients with PD also suffer cognitive fatigue (defined as the general sensation of difficulty in initiating cognitive activity) and cognitive fatigability (defined as "deterioration in the performance of attention tasks over an extended period of time"). Cognitive impairment, cognitive fatigue, and cognitive fatigability affect quality of life in patient with Parkinson's disease. Transcranial direct current stimulation (tDCS) is a noninvasive and safe brain stimulation technique that has been shown to be effective in improving cognitive function in subjects with Parkinson's disease. During tDCS, low-voltage, low amplitude current is passed through a pair of surface electrodes placed over the areas of brain of interest. The specific aim of this study is to examine if atDCS to LDLPFC at 2 milliamps (mA) for 20 minutes daily for 5 days will improve cognitive function and reduce cognitive fatigue and fatigability in PD patients with MCI. The study will examine if the effects may last for two weeks.


Criteria:

Inclusion Criteria: - Clinical diagnosis of PD with at least two of the four diagnostic criteria for PD (tremor, rigidity, bradykinesia, and postural instability) - Meets criteria for MCI (21 ≤ MOCA scores ≤ 26) - Must be able to consent Exclusion Criteria: - Patients with dementia (MOCA < 21) - PD treatment using deep brain stimulation (DBS) - Diagnosis of psychosis - Diagnosis of multiple sclerosis - Diagnosis of stroke - Diagnosis of epilepsy - Diagnosis of chronic obstructive pulmonary disease - Diagnosis of congestive heart failure - Diagnosis of renal failure - Participants not fluent in English


NCT ID:

NCT03191916


Primary Contact:

Principal Investigator
Jau-Shin Lou, MD
Sanford Health

Asenath X Huether, MS
Phone: 701-234-4170
Email: parkinsonsresearch@sanfordhealth.org


Backup Contact:

N/A


Location Contact:

Fargo, North Dakota 58103
United States

Asenath X Huether, MS
Phone: 701-234-4170
Email: parkinsonsresearch@sanfordhealth.org

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: July 23, 2021

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