Boston, Massachusetts 02114

  • Lung Cancer

Purpose:

The goal of this study is to investigate the safety of [68Ga]CBP8 and its efficacy to detect collagen deposition in pulmonary fibrosis.


Study summary:

The investigators have developed [68Ga]CBP8, a gallium-68 labeled collagen binding PET imaging probe, which selectively binds collagen type I. Collagen deposition is a pivotal event in several human conditions including pulmonary fibrosis. The investigator's studies in mice showed that [68Ga]CBP8 binds collagen with high affinity and has excellent pharmacological and pharmacokinetic profiles with high target uptake and low retention in background tissues and organs. [68Ga]CBP8 was shown in a mouse model to be effective for detecting lung fibrosis. [68Ga]CBP8 showed high specificity for pulmonary fibrosis and high target:background ratios in diseased animals. In addition, [68Ga]CBP8 could be used to monitor response to treatment. Ex vivo analysis of lung tissue from patients with IPF supported the animal findings. The investigators thus aim to perform the first in human studies of [68Ga]CBP8: 1. To evaluate the safety of [68Ga]CBP8 and its whole body distribution, metabolism, pharmacokinetics, and radiation burden in healthy volunteers. 2. To establish the accuracy of [68Ga]CBP8-PET to detect radiation-induced fibrosis in lung cancer patients and correlate collagen-targeted [68Ga]CBP8-PET imaging with HRCT and histology in lung cancer patients. 3. To determine whether collagen deposition as assessed by [68Ga]CBP8-PET molecular imaging can predict disease progression in IPF patients and patients with other types of ILD with a fibrotic component.


Criteria:

Inclusion Criteria: Total enrollment for all groups (1, 2, and 3) will not exceed 25 subjects. - Group 1: Healthy subjects - Age greater than 18 years - Be deemed healthy at screening visit as determined by the physician investigator or nurse practitioner, based on the following assessments at Screening: physical examination, medical history, and vital signs - Have the ability to give written informed consent; - No known history of pulmonary disease (excluding pulmonary nodules); - No prior history of tobacco use. Group 2: Lung cancer patient subjects - Eligible patients will be those harboring locally advanced clinical stage IIIA NSCLC who are deemed candidates for multi-modality therapy, i.e. concurrent chemotherapy and radiation followed by pulmonary resection. - Age greater than 18 years - Have the ability to give written informed consent. - No tobacco use within the prior 6 months. Group 3: Subjects with pulmonary fibrosis - IPF (with a UIP or probable UIP pattern); or other forms of interstitial lung disease (ILD), including CTD-ILD, with a fibrotic component as noted by the presence of reticular markings and / or traction bronchiectasis and / or honeycombing on CT; - Age: 40-80 years old; - Have the ability to give written informed consent; - No tobacco use within the prior 6 months Exclusion Criteria: - Electrical implants such as cardiac pacemaker or perfusion pump; - Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, metallic tattoos anywhere on the body, tattoos near the eye, or steel implants ferromagnetic objects such as jewelry or metal clips in clothing; - Pregnant or breastfeeding (a negative quantitative serum hCG pregnancy test is required for females having child-bearing potential before the subject can participate); - Claustrophobic reactions; - Research-related radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months); - Unable to lie comfortably on a bed inside the MR-PET; - Body weight of > 300 lbs (weight limit of the MRI table); - Determined by the investigator(s) to be clinically unsuitable for the study (e.g. based on screening visit and/or during study procedures); - Known history of pulmonary disease (except for pulmonary fibrosis in the study group), recent pneumonia or respiratory tract infections within 6 weeks of enrollment, prior radiation therapy to the thorax (except for the lung cancer patients in aim 2); - Pneumonia or other acute respiratory illness within 6 weeks of study entry (except for pulmonary fibrosis), pneumonia defined with elevated WBC, fever, infiltrate on CXR and need for antibiotics Exclusion criteria specific to Group 2: - Stage IIIA NSCLC patients who undergo definitive bimodality therapy, i.e. chemotherapy and radiation without resection will be excluded.


NCT ID:

NCT03535545


Primary Contact:

Principal Investigator
Sydney B Montesi, MD
Massachusetts General Hospital

Sydney B Montesi, MD
Phone: 617 724 4030
Email: sbmontesi@partners.org


Backup Contact:

Email: Layla.Rahimi@MGH.HARVARD.EDU
Layla Rahimi
Phone: 617 724 5548


Location Contact:

Boston, Massachusetts 02114
United States

Sydney Montesi, MD

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: June 12, 2021

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