Lexington, Kentucky 40511

  • Alcohol Use Disorder


This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.


Inclusion Criteria: - able to speak/read English - not seeking treatment at the time of the study - one binge drinking episode (5+/4+ standard alcoholic drinks per drinking session for men and women, respectively) in the past 30 days - recent alcohol use verified by ethyl glucuronide positive urine, as well as fulfillment of DSM-5 diagnostic criteria for alcohol use disorder - ECG within normal limits - otherwise healthy - body mass index of 19-35 - females using an effective form of birth control and not pregnant or breast feeding - judged by the medical staff to be psychiatrically and physically healthy - able to abstain from alcohol for 12 hours prior to session - no contraindications/allergies to duloxetine or methylphenidate



Primary Contact:

Principal Investigator
Craig Rush, PhD
University of Kentucky

Frances Wagner, RN
Phone: 859-257-5388
Email: fpwagn2@uky.edu

Backup Contact:


Location Contact:

Lexington, Kentucky 40511
United States

Frances Wagner, RN
Phone: 859-257-5388
Email: fpwagn2@uky.edu

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: June 13, 2021

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