Baltimore, Maryland 21205


Purpose:

This is a randomized, controlled trial to slow cognitive decline in adults undergoing hemodialysis (HD). The investigators will test three interventions cognitive training (CT), exercise training (ET), and combined cognitive and exercise training (CT+ET) relative to standard of care (SC).


Study summary:

This will be a two by two factorial, randomized, controlled trial to slow cognitive decline in adults undergoing hemodialysis (HD). The investigators primary objective is to determine if receiving cognitive training (tablet-based brain games), exercise training (stationary foot pedal), or combined cognitive and exercise training preserves executive function relative to those with standard of care . The secondary objectives are to compare the rates of end stage renal disease (ESRD)-specific clinical outcomes and patient centered outcomes among those receiving CT, or ET, or CT+ET relative to those in SC. The investigators will formally test whether receiving CT or ET will preserve executive function and receiving combined CT+ET will preserve executive function better than CT or ET alone.


Criteria:

Inclusion Criteria: - 18 years or older at enrollment - English speaking - within 3 months to 3 years of initiating hemodialysis - receiving hemodialysis at participating dialysis centers Exclusion Criteria: Patients with the following conditions will be excluded: - Pregnancy - Angina Pectoris - Chronic lung disease requiring oxygen - Musculoskeletal conditions that limit mobility - Upper or lower extremity amputation - Orthopedic disorders exacerbated by physical activity - Femoral arteriovenous (AV) access - Hepatitis B infection - Blindness/Legal blindness In addition to conditions outlined above, patients who are currently incarcerated will be excluded from the study.


NCT ID:

NCT03616535


Primary Contact:

Principal Investigator
Mara McAdams Demarco, PhD
Johns Hopkins University

Mara McAdams DeMarco, PhD
Phone: 410-502-1950
Email: mara@jhu.edu


Backup Contact:

Email: mmooney6@jhmi.edu
Malu B Steckel, DVM
Phone: 443-287-0613


Location Contact:

Baltimore, Maryland 21205
United States

Malu B. Steckel, DVM
Phone: 443-287-0613
Email: mmooney6@jhmi.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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