West Lafayette, Indiana 47907


Purpose:

Consumption of slowly digestible carbohydrates can elicit higher satiety feeling compared to rapidly digestible carbohydrates, however not all individuals respond the same. The physiological mechanism that accounts for the satiety effect and the lack of consistency among subjects is not fully understood. The overall aim of this research is to determine if consumption of slow digestible carbohydrates (e.g., millet couscous) can induce non-responding subjects (i.e., with rapid gastric emptying) to activate the ileal brake and delay rate of gastric emptying.


Study summary:

The purpose of this study is to understand how consumption of slowly digestible carbohydrate (e.g. millet couscous) over time may affect overall health. The investigators will be recruiting 15 volunteers for this study. To be eligible for this study, you need to be between 18 and 50 years old, have a normal Body Mass Index, have a normal fasting blood glucose level, be free of any gastrointestinal diseases, diabetes, cardiovascular diseases, be free of wheat allergens, gluten intolerance or sensitivities, and allergy to millet, and not be pregnant or nursing. If you have any questions about the criteria, please ask the person consenting you. In this study participants will consume 200-300 g slowly digestible carbohydrates/day for 30 days. For the duration of the study there will be 5 testing days, in which participants will consume a meal with a C13 tracer, breath into test bags and wear a glucose monitor. During testing days participants will be required to stay in the laboratory. Testing day sessions will last about 4 hours with a short 30-minute visit the day prior to install glucose monitor. For non-testing days participants will consume meal in the laboratory but are not required to stay. The purpose of this study is to evaluate the continuous effect of slowly digestible carbohydrates consumption on gastric emptying and its potential health benefits.


Criteria:

Inclusion Criteria: - BMI 18.5 - 25.0 kg/m2 - 18 - 50 years - Normal fasting blood glucose Exclusion Criteria: - History of gastrointestinal disease - Diabetes - Pregnant and nursing women - Wheat and/or gluten allergies or sensitivities - Allergy to specific sources of slowly digestible carbohydrates


NCT ID:

NCT03630263


Primary Contact:

Principal Investigator
Regan C Bailey, PhD
Purdue University

Bruce R Hamaker, PhD
Phone: 765.494.5668
Email: hamakerb@purdue.edu


Backup Contact:

Email: ptorresa@purdue.edu
Pablo C Torres Aguilar, MS
Phone: 2176074379


Location Contact:

West Lafayette, Indiana 47907
United States

Bruce R Hamaker, PhD
Phone: 765-494-5668
Email: hamakerb@purdue.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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