Hershey, Pennsylvania 17033


This human study will test the impact of dietary supplement vegicaps containing Korean Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and other germs and natural killer (NK) cells that kill virus-infected cells and cancers. The investigators had done an earlier study with Korean Angelica supplement and discovered even a single dose of it increased blood neutrophils and NK cells within 24 h. In the new study, Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo) capsules. This is to make sure the immune boosting actions are really from the Korean Angelica supplement.


Inclusion Criteria: - Subjects weighing between 100 to 240 pounds; their body mass index (BMI) should be in the range of 19 to 30 - Subjects having normal hepatic, renal function as assessed by history, physical and clinical chemistry analysis (CMP eGFR, see supporting document for normal reference ranges). - Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80 mm Hg) Exclusion Criteria: - Subjects positive for HIV, HBV and HCV (self-reported) - Subjects taking any kind of prescription medications regularly or within 10 days of the study will be excluded. Therefore, subjects with diabetes, major cardiovascular diseases, cancer, severe hypertension, severe hepatic cirrhosis or cirrhosis of the liver, and kidney disease (self-reported) will be excluded. - Subjects using tobacco products, nicotine patches and excessive alcohol - Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q, Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10 days of the study. - Non-English-speaking subjects



Primary Contact:

Principal Investigator
Junxuan Lu, Ph.D.
Penn State College of Medicine

Deepkamal N Karelia, Ph.D.
Phone: 717-531-0003 ext. 285476
Email: dkarelia@pennstatehealth.psu.edu

Backup Contact:


Location Contact:

Hershey, Pennsylvania 17033
United States

Deepkamal N Karelia, Ph.D.

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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