Pittsburgh, Pennsylvania 15213


The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.

Study summary:

The overall goal of this proposal is to determine new molecular and cellular features that define tumor subtypes that are clinically actionable, may drive important changes in patient management, and/or elucidate novel chemotherapeutic options. Skull base tumors are currently diagnosed based on histopathologic criteria, on which post-operative management is based. However, the investigators hypothesize that each tumor type (eg. chordoma or chondrosarcoma) will have molecular and/or cellular subcategories that will redefine how to categorize and diagnose patients, predict clinical outcome, and optimally design a patient-specific management strategy. In addition, we aim to catalogue changes that occur after treatment after surgical resection, chemotherapy, and/or radiation by comparing primary and recurrent tumors.


Inclusion Criteria: - Diagnosis of a skull base tumor Exclusion Criteria: - Insufficient tumor sample at time of resection



Primary Contact:

Principal Investigator
Paul Gardner, MD
Associate Professor

Benita Valappil, MPH
Phone: 412-864-1744
Email: valappilb2@upmc.edu

Backup Contact:


Location Contact:

Pittsburgh, Pennsylvania 15213
United States

Benita Valappil, MPH
Phone: 412-864-1744
Email: valappilb2@upmc.edu

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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