Pittsburgh, Pennsylvania 15213


Purpose:

The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.


Study summary:

The overall goal of this proposal is to determine new molecular and cellular features that define tumor subtypes that are clinically actionable, may drive important changes in patient management, and/or elucidate novel chemotherapeutic options. Skull base tumors are currently diagnosed based on histopathologic criteria, on which post-operative management is based. However, the investigators hypothesize that each tumor type (eg. chordoma or chondrosarcoma) will have molecular and/or cellular subcategories that will redefine how to categorize and diagnose patients, predict clinical outcome, and optimally design a patient-specific management strategy. In addition, we aim to catalogue changes that occur after treatment after surgical resection, chemotherapy, and/or radiation by comparing primary and recurrent tumors.


Criteria:

Inclusion Criteria: - Diagnosis of a skull base tumor Exclusion Criteria: - Insufficient tumor sample at time of resection


NCT ID:

NCT03759717


Primary Contact:

Principal Investigator
Paul Gardner, MD
Associate Professor

Benita Valappil, MPH
Phone: 412-864-1744
Email: valappilb2@upmc.edu


Backup Contact:

N/A


Location Contact:

Pittsburgh, Pennsylvania 15213
United States

Benita Valappil, MPH
Phone: 412-864-1744
Email: valappilb2@upmc.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: February 04, 2019

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