Pittsburgh, Pennsylvania 15213

  • Depression


For the proposed 2-year study, the investigators will conduct a within-subject, counterbalanced investigation using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to examine the acute effects of theta-burst stimulation (TBS) on function in dorsomedial prefrontal cortex (dmPFC) in 35 young adults with depression (18-25 years, 50% female).

Study summary:

Each participant will undergo 3 sessions of TMS, one each of continuous and intermittent TBS--with the goal of decreasing or increasing dmPFC responding, respectively--and one of sham TBS. Session order will be counterbalanced, with a double-blind approach to condition. Brain function, behavior, and mood will be assessed before and after each TBS session. Broadly, the investigators predict that inhibitory TBS to the dmPFC will enhance neural, behavioral, and subjective aspects of reward function by reducing dmPFC function and dmPFC connectivity with the ventral striatum (VS).


Inclusion Criteria: • DSM-5 Diagnosis of Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia), Other Specified Depressive Disorder, or Other Unspecified Depressive Disorder Exclusion Criteria: - Bipolar disorder, substance dependence, or lifetime history of psychosis - Neurological disorder (e.g., seizure disorder) - Pregnant - MRI contradictions: claustrophobia, permanent orthodontic devices, metal implants or other forms of metal in the body that cannot be removed



Primary Contact:

Principal Investigator
Erika E Forbes, Ph.D.
The University of Pittsburgh

Erika E Forbes, Ph.D.
Phone: 412-383-5438
Email: forbese@upmc.edu

Backup Contact:

Email: buckleymn@upmc.edu
Nicole Buckley, B.A.
Phone: 412-337-8886

Location Contact:

Pittsburgh, Pennsylvania 15213
United States

Erika E Forbes, Ph.D.
Phone: 412-383-5438
Email: forbese@upmc.edu

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: July 01, 2022

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