Minneapolis, Minnesota 55455


Purpose:

The long-term goal of this project is to examine the effects of cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD) on brain structure and function


Study summary:

A growing body of evidence suggests that hyperglycemia in type 1 and type 2 diabetes is associated with alterations in brain structure and cognitive impairment. People with cystic fibrosis related diabetes (CRFD) are exposed to hyperglycemia as seen in other forms of diabetes, and cystic fibrosis is also associated with chronic systemic inflammation. Both hyperglycemia and chronic inflammation have been postulated to affect brain structure and function. Cystic fibrosis trans-membrane conductance regulator (CFTR). protein is widely expressed in the neurons of the brain including in the hippocampus The hippocampus plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of metabolic stressors. The expression of CFTR in neurons has several potential implications for central nervous system function, including cognition. The long-term goal of this project is to examine the effects of cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD) on brain structure and function.


Criteria:

Inclusion Criteria: patients with Cystic fibrosis healthy controls Exclusion Criteria: For both Groups - History of stroke - History of epilepsy - History of neurosurgical procedures - Past or current history of severe psychiatric illness - Pass or current history of alcohol or substance abuse - Presence of metallic substances in body or inability to remove before imaging procedure - History of claustrophobia or known inability to tolerate MRI - Current pregnancy - Inability to consent


NCT ID:

NCT03820349


Primary Contact:

Amir Moheet
Phone: 6126243209
Email: mohee002@umn.edu


Backup Contact:

Email: kumar045@umn.edu
Anjali Kumar
Phone: 6126240470


Location Contact:

Minneapolis, Minnesota 55455
United States

Amir Moheet, MD
Phone: 612-624-3209
Email: mohee002@umn.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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