Houston, Texas 77030


This early phase I trial studies how well transcranial direct current stimulation works in reducing pain in cancer patients with chemotherapy induced peripheral neuropathy. Transcranial direct current stimulation is used for patients with brain injuries such as strokes as well as for mental health issues such as depression and may help to control pain in cancer patients with chemotherapy induced peripheral neuropathy.

Study summary:

PRIMARY OBJECTIVES: I. To evaluate the efficacy of transcranial direct current stimulation (tDCS) in reducing chemotherapy induced painful peripheral neuropathy (CIPPN). Ia. Evaluate the change in pain scores Ib. Assess for changes in other symptoms (i.e insomnia, feeling of well-being, depression and anxiety). SECONDARY OBJECTIVES: I. To evaluate the following with the treatment of tDCS: Ia. Assess for changes in using pain medications. Ib. Assess for changes in functioning (daily activities). Ic. Assess for changes in quality of life. Id. Assess for changes in neuropathy. Ie. Assess overall satisfaction with the tDCS treatment. TERTIARY OBJECTIVES: I. To evaluate tDCS treatment related side-effects. OUTLINE: Patients undergo tDCS once daily (QD) over 20 minutes 5 days each week (Monday-Friday) for 3 weeks. After completion of study treatment, patients are followed up weekly for 3 weeks and at 4-6 weeks.


Inclusion: - Age greater than or equal to 18 years. - Able to give a Voluntary written consent. - Cancer patients with chemotherapy induced peripheral neuropathy of at least 3 months duration.. - Pain and/or tingling of at least 4/10 Exclusion: - History of seizure - History of migraine headache - History of brain cancer and/or brain metastasis



Primary Contact:

Principal Investigator
Salahadin Abdi
M.D. Anderson Cancer Center

Salahadin Abdi
Phone: 713-745-7246
Email: sabdi@mdanderson.org

Backup Contact:


Location Contact:

Houston, Texas 77030
United States

Salahadin Abdi
Phone: 713-745-7246

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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