Grand Forks, North Dakota 58203

  • Overweight


The purpose of this research is to determine the blood signals that promote health and well-being in response to exercise at different intensities.

Study summary:

Most studies find a dose-response relationship between exercise participation and all-cause mortality. In contrast, physical inactivity and consequent overweight or obese status is associated with a cadre of health consequences. Frequently, comorbidities of obesity are mechanistically linked via chronic low grade inflammation stemming from increases in adiposity. Although exercise is known to combat obesity and obesity related disease states, the mechanisms of action are not fully understood. Therefore, the investigators propose the following study in an attempt to elucidate anti- and pro-inflammatory endocrine responses to exercise. Initial studies in animal models have provided evidence that exercise induces long-term anti-inflammatory effects, potentially via myokine signaling following skeletal muscle activation. Humans are an ideal study population as the investigators can prescribe multiple exercise protocols that mimic human behavior, and control exercise intensity to meet recommendations. Also, humans allow the investigators to collect larger plasma samples and therefore measure more circulating proteins of interest over multiple time-points. Finally, the investigators can select individuals that exercise at different frequencies, allowing the investigators to analyze the differences in endocrine responses to exercise over differing levels of fitness. In summary, a human model will allow for a much better understanding of the human condition.


Inclusion Criteria: - No tobacco use - Not pregnant, lactating, or planning to become pregnant in the next 6 months - Regular menses for the past 6 months - No use of hormone replacement for metabolic conditions (use of hormonal contraceptives are not exclusionary) - No physical limitations - Has the ability to safely perform exercise Exclusion Criteria: - Has no major health problems - Cannot have known cardiovascular (cardiac, peripheral vascular, cerebrovascular), pulmonary (COPD, interstitial lung disease, cystic fibrosis) or metabolic (diabetes, thyroid disorders, renal or liver disease) disease



Primary Contact:

Principal Investigator
James Roemmich, PhD
USDA Grand Forks Human Nutrition Research Center

James Roemmich, PhD
Phone: 701-795-8272

Backup Contact:

William Siders, PhD
Phone: 701-795-8430

Location Contact:

Grand Forks, North Dakota 58203
United States

Angela J Scheett, MPH, RD
Phone: 701-795-8386

Site Status: Recruiting

Data Source:

Date Processed: July 31, 2021

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