Columbia, Missouri 65211

  • Diet Intervention

Purpose:

The proposed study has two primary objectives i.e. to examine how improvements in diet quality via a personalized dietary intervention 1) benefit cardiometabolic outcomes in young Black adults differentially compared to non-Hispanic White adults, and 2) improve carbohydrate and lipid metabolism in relation to the gut microbiome.


Study summary:

The study is an 8-wk randomized, controlled, parallel arm clinical trial in which participants (age: 18-25 years, BMI: 25-45 kg/m2, race/ethnicity: Black or White) will be block randomized to a personalized dietary intervention or to receive conventional dietary advice. Outcomes assessed will include metabolites involved in carbohydrate and lipid regulation, gut microbiome composition, and cardiometabolic biomarkers.


Criteria:

Inclusion criteria: - Age: 18-25 years of age - BMI: 25-45 kg/m2 - Black including those of Hispanic ethnicity, and Non-Hispanic White individuals - Willingness to consume nuts, fruits and vegetables - Willing to comply with study protocol - Consistent diet and activity patterns for 4 weeks - Weight stable (≤4 kg change over the last 3 months) (Self-reported) - Non-smoker >1 year or more Exclusion Criteria: - Nuts, fruits, vegetable allergies - Illicit drug use - Medications that affect metabolism or appetite - Anti-inflammatory medications and antibiotics - Diabetes, hypertension, cardiovascular disorders or dyslipidemia requiring drug therapy - Gastrointestinal disease and/or bariatric surgery - HIV positivity - Pregnant or lactating individuals


NCT ID:

NCT04635917


Primary Contact:

Principal Investigator
Jaapna Dhillon, PhD
University of Missouri-Columbia

Jaapna Dhillon, PhD
Phone: 573-884-2103
Email: jdhillon@missouir.edu


Backup Contact:

Email: wellyr@missouri.edu
Rebecca Welly, MS
Phone: 660-233-0689


Location Contact:

Columbia, Missouri 65211
United States

Jaapna Dhillon, PhD
Phone: 573-884-2103
Email: jdhillon@missouri.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: August 03, 2021

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