Philadelphia, Pennsylvania 19104

  • Craniotomy Surgery


This study compares the standard of care to the standard of care plus the administration of bupivacaine or liposomal bupivacaine in patients receiving craniotomies.

Study summary:

Objective: To assess the effectiveness of analgesia by scalp nerve block with various agents in the first 72 hours following elective craniotomy. The investigators will employ a randomized, single-blinded, prospective study design. Participants will be randomized 1:1:1 into one of three treatment groups: Bupivacaine, Liposomal Bupivacaine, and Saline.


Inclusion Criteria: - ≥18 years of age - Need for elective supratentorial craniotomy - Preoperative GCS > 13 Exclusion Criteria: - Preoperative GCS ≤ 13 - Child (<18 years of age) - Inability to understand or use the visual analog scale (VAS) - Proven or suspected allergy to local anesthetics - Craniotomy incision extending beyond the field of the block - Patients chronically (more than 2 wk) treated with narcotic medications - Previous scalp incision - Bilateral craniotomies - Allergies to local anesthetics - GCS verbal score < 4 after extubation - Patients whose surgeries extend past 6 hours (will be placed on standard of care and removed from study) - Patients currently on ergot-type oxytoxic drugs, MAOIs, or certain antidepressants - Lactating Mothers



Primary Contact:

Principal Investigator
Timothy H Lucas, MD
University of Pennsylvania

Backup Contact:


Location Contact:

Philadelphia, Pennsylvania 19104
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: June 13, 2021

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