Cincinnati, Ohio 45229

  • Major Depressive Disorder


In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in Autism Spectrum Conditions.

Study summary:

The overarching goal of this study is to examine treatment effects and elucidate the physiological biomarkers of a newer form of non-invasive brain stimulation therapy on refractory depression in a sample of participants with ASC (autism spectrum condition). Aim 1: To compare the efficacy of 30-sessions of bilateral (BL) versus unilateral (UL) Theta Burst Stimulation to the dorsolateral prefrontal cortex (DLPFC) on depression severity in youth/young adults with ASC and co-occurring refractory major depressive disorder (MDD). Aim 2: To identify physiological markers of target engagement of successful response to either UL or BL on depression severity in youth with ASC and co-occurring refractory MDD. These physiological markers include high-resolution electroencephalography (EEG) markers, social eye-tracking, and handgrip strength (collected via NIH toolbox's motor toolbox domain). Aim 3: To identify feasibility of BL and UL in participants with ASC including systematic measures of safety and tolerability. This includes clinical measures such as rate of hospitalization and medication use.


Inclusion Criteria: - Have been diagnosed on the autism spectrum - Have been diagnosed with depression and have failed one or more evidence-based antidepressant treatments (e.g. a Selective Serotonin Reuptake Inhibitor, talk therapy like Cognitive Behavioral Therapy) - Do not have an intellectual disability Exclusion Criteria: - Substance use disorder - Presence of metallic foreign bodies or implanted medical devices - History of epilepsy - Prior rTMS treatment - For female subjects of child bearing potential, current pregnancy



Primary Contact:

Principal Investigator
Ernest Pedapati, MD
Children's Hospital Medical Center, Cincinnati

Elizabeth J Blank
Phone: 513-803-8635

Backup Contact:

Grace Westerkamp

Location Contact:

Cincinnati, Ohio 45229
United States

There is no listed contact information for this specific location.

Site Status: Recruiting

Data Source:

Date Processed: June 28, 2022

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