Clinical Trial 12751

San Antonio, TX 78209

Study Summary:

ICON Development Solutions is conducting a research study in overweight men and women ages 18-60.

The purpose of the study is to compare an investigational medication with an approved medication, Actos, for effectiveness in reducing liver fat associated with nonalcoholic fatty liver disease. Qualified participants will receive either the study drug, the approved drug or a placebo. All study medications or placebo will be given orally in tablet or capsule form.

Vital signs, diet counseling, ECGs, an ultrasound, and physical examinations will be performed, and blood and urine samples will be obtained during this study. Up to two MRIs may also be performed.

Qualified Participants Must:

• Be between the ages of 18 and 60
• Have a BMI greater than or equal to 32 kg/m2
• Have maintained a stable weight for 4 weeks prior to start of the study
• If female, be surgically sterile or postmenopausal
• Not have participated in a research study or received any other investigational drug in the past four weeks prior to screening
• Complete up to 3 screening visits, 5 outpatient visits, 23 telephone calls and 1 follow-up outpatient visit

Qualified Participants May Receive:

All study-related exams at no cost and compensation for time and travel as follows:
Up to $75.00 for each ultrasound and MRI visit
Up to $125.00 for each outpatient visit
Up to $25.00 for each completed telephone contact

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.