Expired Study
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Clinical Trial 13361

Bethesda, MD 20892


Study Summary:

Volunteers Needed for a Live Influenza Vaccine Research Study

About the study

Researchers at the National Institutes of Health (NIH) are testing an investigational Adenovirus vaccine. This type of virus typically causes symptoms seen in the common cold and flu. The goal of this research study is to learn whether the investigational vaccine is safe and causes a strong immune response. This will help researchers in the development of future vaccines for common illnesses.

Who can participate?

You may be eligible for the study if you:

  • Are between 18–49 years old and in good health
  • Have not had your tonsils removed
  • Are willing to be hospitalized for one week at NIH
  • Do not live or work closely with:
    • People who have weakened immune systems caused by chronic illness
    • Children younger than 5 years old
    • Elderly people
    • Pregnant women

What does the study involve?
Participants will be asked to make a visit to the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, for a blood draw, medical history, and physical exam. Participants will return to NIH to receive the investigational vaccine, which will be applied to the tonsils in the back of the throat, and will need to stay in the inpatient unit for 7 days. Because the vaccine may cause cold symptoms, members of the participant's household must take part in the study and will have to visit NIH twice for a physical exam and blood draw but will not receive the vaccine.

Where is the study taking place?
The screening and studies are being conducted at the Warren Grant Magnuson Clinical Center (Building 10) at the NIH in Bethesda, Maryland. The NIH campus is accessible by car and public transportation.

How much does it cost?
There is no charge to participate in the study. All screening and study-related medical care and procedures are provided free of charge.

Will I receive payment of some kind?
Yes, you and your household members will be compensated for participation. Transportation and other expenses may also be covered.


Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.