Clinical Trial 13395

San Antonio, TX 78209

Study Summary:

ICON Development Solutions is conducting a research study in healthy men ages 18-45. This study is being done to see how safe and tolerable an investigational new drug is. The investigational study drug is being developed for the treatment of chronic pain.

Qualified participants will receive 44 injections of study drug or placebo in the forearm using one of six different methods. The study will also test the most effective delivery method for the medication.

Vital signs and physical examinations will be performed, and blood and urine samples will be obtained during this study.

Qualified Participants Must:

• Be a healthy male between the ages of 18 and 45
• Have a BMI between and 20 and 30 kg/m2
• Not have participated in any investigational drug or device study within 30 days prior to the start of this study
• Have not participated in any previous study for the investigational drug AGN-214868
• Have not received BOTOX®
• Not have not used tobacco or tobacco-containing products within the past 30 days
• Not have any history of substance abuse
• Not have significant skin allergies, active dermatologic conditions (such as acne or psoriasis), body art, significant scarring or birthmarks on the inside of the forearms
• Not have any known allergy or sensitivity to AGN-214868 or its components
• Not have used skin products, including patches, sun lotion, over-the-counter or prescription products, or any form of hair removal (including shaving, waxing or chemicals), or laser tattoo removal on their forearms for 2 weeks prior to screening
• Complete 1 screening visit, 1 overnight stay, 2 outpatient visits and one telephone follow up visit

Qualified Participants May Receive:

All study-related exams at no cost; Compensation up to $1,025.00 for time and travel

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.