Clinical Trial 2672

Voorhees, NJ 08043

Study Summary:

Gastrointestinal (GI) randomized event and safety open-label NSAID study (GI-reasons): A randomized, open-label, blinded-endpoint, parallel-group trial of GI safety of SC-58635 compared with non-selective nonsteroidal antiinflammatory drugs (NSAIDS) in osteoarthritis patients

Qualified Participants Must:

• Be at least 55 years of age with a diagnosis of osteoarthritis requiring daily anti-inflammatory analgesic therapy
• Have no history of GI hemorrhage or ulceration less than 90 days prior to screening visit
• Have negative fecal occult blood test at screening
• Not be on Lithium, or Plavix
• Not have a history of myocardial infarction, stroke, transient ischemic attacks, or previous revascularization surgery
• Not have congestive heart failure
• Not have history of alcohol/substance abuse
• Have no history of chronic IBS, renal insuff, or cirrhosis of liver
• Not be enrolled in any other investigational trial concurrently within 30 of entry into this study
• Not have history of malignancy in past 5 years other than surgically treated basal cell carcinoma

Qualified Participants May Receive:

Study medications, all study related blood work, and diagnostic studies at no charge.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.