Clinical Trial 37933

Los Angeles, CA 90095

Study Summary:

The purpose of this research is to compare the effects of Tai Chi Chih to health and wellness education in older adults
aged 60 or older, who suffer from symptoms of depression. Approximately 220 subjects will participate in this study.
We will measure cognitive functioning, performance, and mood in older subjects and compare the results of
the Tai Chi Chih and health and wellness education classes.

You will be randomly assigned to either a weekly 60 minute session of Tai Chi Chih or a health and wellness
educational course in the beginning of the trial. You will have a 50% chance of receiving a Tai Chi Chih class and a
50% chance of receiving health and wellness education. We will also conduct three brain MRI scans: one before and
one after the 12-week training, as well as one at the final 12-month follow-up visit. The first appointment
includes a psychiatric and medical evaluation. If you continue to qualify for the study, the entire study can last up to 1

Protocol ID:IRB#15-000184 UCLA IRB Approved Approval Date: 9/18/2018 Through: 12/13/2018 Committee: Medical IRB 3


Qualified Participants Must:

• Be 60 years of age or older
• Currently on a stable form of depression treatment

Qualified Participants May Receive:

Participants will receive up to $450 and reimbursement for parking.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.