Expired Study
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Clinical Trial 3802

Los Angeles, CA 90095

Study Summary:

The purpose of this study is to examine measurements of the expression of the colonic corticotrophin releasing-factor (CRF), which is a hormone responsible for stress response in relation to Irritable Bowel Syndrome (IBS). We intend to identify sex differences in the expression of the colonic CRF system, explore the relationships of the CRF system and measure of the body’s stress response and immune system. It is our intent that this study will improve our understanding of the causes of IBS, which may lead to improved treatment. Your participation in this research is not expected or intended to provide you with any specific diagnosis or treatment benefits.

Qualified Participants Must:

• Be 18-55 years of age
• Be ambulatory
• Have abdominal pain or discomfort at least 3 days per month OR have no abdominal pain (healthy control)
• Speak the English language fluently due to the standardized psychiatric assessments involved
• Not have unstable cardiovascular, renal, hepatic, pulmonary, endocrine, metabolic, hematologic, or gastrointestinal condition
• Not have current evidence, or history of (at any time in the past): Inflammatory bowel disease (Crohn’s disease or ulcerative colitis), Gastrointestinal surgery (exceptions: appendectomy, cholecystectomy, benign polypectomy, and hiatus hernia), Gastroparesis, Gastrointestinal malignancy, Gastrointestinal obstruction, Carcinoid syndrome, Chronic pancreatitis, Amyloidosis
• Not have current evidence of (within the past 6 months): Diverticulitis, Duodenal ulcer, Erosive esophagitis, any grade, Gastric ulcer, Acute pancreatitis, Ileus, Symptomatic cholelithiasis (unless the subject has had a therapeutic ERCP, or undergone a cholecystectomy), Symptomatic gastroesophageal reflux disease not controlled by a stable dose of medication
• Not have any evidence or treatment of malignancy within the previous 5 years
• Not have a history of alcohol or substance abuse within the previous 5 years
• Not have used an investigational drug or participated in an investigational study within 30 days of screening
• Not be pregnant
• Not be breast-feeding

Qualified Participants May Receive:

Up to $200 compensation (plus free parking). Free physical examination, free colonic examination, and free psychosocial evaluation.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.