Clinical Trial 3974

Hickory, NC 28602

Study Summary:

Purpose:  To determine if treatment with motesanib AMG 706 in combination with paclitaxel and carboplatin improves overall survival compared to treatment with placebo in combination with paclitaxel and carboplatin in patients with advanced NSCLC (non-small cell lung cancer).


Inclusion Criteria:

  • Histologically confirmed, unresectable stage 111B with pericardial or pleural effusion or stage IV or recurrent NSCLC.
  • Ability to take oral medications

Exclusion Criteria:

  • Any prior chemotherapy for advanced NSCLC
  • Pregnant or breastfeeding woman.
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Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.