Summary:
The purpose of this study is to understand how sleep disruption affects the way the brain works and how sleep disruption is related to drug responses and pain. This knowledge is needed to develop better ways to manage pain. The study will be conducted in two major parts. Part 1 involves two outpatient screening visits in our laboratory, one of which will include administration of an FDA approved pain medication. Part 2 involves an in-patient stay in the Clinical Research Unit at the Johns Hopkins Bayview Medical Center for four consecutive nights and days. Two of these nights will involve experimental sleep deprivation. There will also be an MRI, a PET scan, and another administration of an FDA approved pain medication.
Qualified Participants Must:
• Are a healthy, good sleeper
• Are between the ages of 18-48
• Have taken an opioid pain medication at some point in your life (e.g. Oxycontin, Percocet, Vicodin, Codeine, Morphine, Dilaudid, etc)
• Non smoker
• No chronic pain
Qualified Participants May Receive:
Compensation up to $1205.