Summary:
If you or a family member have head and neck cancer, you may want to consider the LUMINOS-103 study.
What is the purpose of LUMINOS-103?
LUMINOS-103 will explore if an investigational drug called PVSRIPO is safe and effective in people with head and neck squamous cell carcinoma.
What is the investigational medication?
PVSRIPO is a modified version of the poliovirus vaccine, which is given to children throughout the world for the prevention of poliomyelitis (polio). These changes ensure PVSRIPO cannot cause polio but can still attack cancer cells. PVSRIPO can attach to and enter tumor cells to cause damage and activate an anti-tumor immune response to help eliminate the cancer cells.
Who can participate in LUMINOS-103?
You may be eligible to participate in the study if you:
- Are ≥ 18 years of age at the time of entry into the study
- Have been diagnosed with head and neck squamous cell carcinoma, and have
- Are planning to have a surgery to remove your head and neck tumors, or
- Recurrent or metastatic disease, meaning the cancer has come back after it was initially removed and/or it has spread outside of the head and neck region and you have a tumor that is safe to inject