Clinical Trial 48337

Phoenix, AZ 85013


The Ivy Brain Tumor Center at Barrow Neurological Institute, a nonprofit translational research program, is conducting a Phase 0 clinical trial to evaluate infigratinib in patients with recurrent high-grade glioma driven by FGFR (fibroblast growth factor receptor) genetic alterations.

The goal of this study is to confirm that infigratinib can cross the blood-brain barrier. Patients with positive results may receive continued treatment in an expansion arm of the trial. We will also confirm if the study drug is hitting the molecular targets.

  • FGFR (fibroblast growth factor receptor) genetic alterations have been shown to spur growth in malignant tumors.
  • Five to seven percent of glioblastoma patients’ tumors are driven by FGFR signaling.
  • Tumors relying on the FGFR gene fusion may demonstrate an ‘oncogene addiction’ that causes them to rely on this genetic anomaly to survive.
  • Infigratinib is an orally administered, FGFR1-3 selective tyrosine kinase inhibitor from QED Therapeutics, a subsidiary of BridgeBio Pharma, Inc.

  • You are 18 years or older
  • You have had prior resection (surgical removal) of a histologically diagnosed high-grade glioma (III and IV)
  • You have been treated with radiation and a chemotherapy drug called temozolomide
  • Your doctor has told you that your tumor has recurred (come back) or has progressed (grown or changed)
  • You have enough archival tumor tissue available from previous surgery to conduct genetic testing for the presence of FGFR3-TACC3 fusion gene or mutations in the FGFR1 and 3 genes.

Qualified Participants May Receive:

As part of a clinical trial at the Ivy Brain Tumor Center, the study drugs will be provided free of charge, however, the patient and/or their health plan/insurance company will be responsible for some or all of the costs of treating the tumor in the study, including any standard medical care such as surgical resection.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.