Clinical Trial 48337

Phoneix, AZ 85013


Summary:

The Ivy Brain Tumor Center at Barrow Neurological Institute, a nonprofit translational research program, is conducting a Phase 0 clinical trial to evaluate infigratinib in patients with recurrent high-grade glioma driven by FGFR (fibroblast growth factor receptor) genetic alterations.

The goal of this study is to confirm that infigratinib can cross the blood-brain barrier. Patients with positive results may receive continued treatment in an expansion arm of the trial. We will also confirm if the study drug is hitting the molecular targets.

  • FGFR (fibroblast growth factor receptor) genetic alterations have been shown to spur growth in malignant tumors.
  • Five to seven percent of glioblastoma patients’ tumors are driven by FGFR signaling.
  • Tumors relying on the FGFR gene fusion may demonstrate an ‘oncogene addiction’ that causes them to rely on this genetic anomaly to survive.
  • Infigratinib is an orally administered, FGFR1-3 selective tyrosine kinase inhibitor from QED Therapeutics, a subsidiary of BridgeBio Pharma, Inc.


Criteria:
  • You are 18 years or older
  • You have had prior resection (surgical removal) of a histologically diagnosed high-grade glioma (III and IV)
  • You have been treated with radiation and a chemotherapy drug called temozolomide
  • Your doctor has told you that your tumor has recurred (come back) or has progressed (grown or changed)
  • You have enough archival tumor tissue available from previous surgery to conduct genetic testing for the presence of FGFR3-TACC3 fusion gene or mutations in the FGFR1 and 3 genes.


Qualified Participants May Receive:

As part of a clinical trial at the Ivy Brain Tumor Center, the study drugs will be provided free of charge, however, the patient and/or their health plan/insurance company will be responsible for some or all of the costs of treating the tumor in the study, including any standard medical care such as surgical resection.


Available At:

St. Joseph's Hospital and Medical Center

Phoneix, AZ 85013
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Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.