There are two study vaccines for this clinical trial, eOD-GT8 60mer mRNA and Core-g28v2 60mer mRNA Vaccines. You might receive one or both in combination. The eOD-GT8 60mer mRNA and Core-g28v2 60mer mRNA vaccines both include a short segment of messenger ribonucleic acid (mRNA). The mRNA is a genetic code that tells cells how to make a protein. For both the HIV vaccines being tested in this study, the mRNA encodes for a protein that is designed to look and behave like the envelope protein, the protein that sits on top of the outer surface of HIV, the virus that causes AIDS. The mRNA is entirely made in a laboratory. When injected into the body, the mRNA causes some cells to make that viral protein, which can trigger an immune response. If the person is later infected, their immune system remembers the protein from the prior vaccination which may help it to fight the invading virus. The mRNA vaccines degrade naturally and do not persist in the body.In animal testing, eOD-GT8 60mer mRNA and Core-g28v2 60mer mRNA Vaccines have been shown to be safe and able to start the body’s immune system along the pathway to make antibodies against the HIV virus.The study vaccines are mixed with saline before being injected.
It is absolutely IMPOSSIBLE to get HIV infection or AIDS from these vaccines.
Will I be paid for my participation in research?If you agree to take part in this research study, we will pay you for every study visit that you complete. This will cover your time, inconvenience, and travel expenses to and from the study clinic. You will be given $125 for each vaccination visit, $75 for each leukapheresis visit, and $50 for all other in-clinic visits. You will be given $25 for scheduled telephone, text, or email contacts. Depending on which group you are assigned to, you may receive between $625 and $1350 in total for attending all study visits. The study vaccine(s), study-related tests and visits are free of charge to you.