Clinical Trial 49220

Bronx, NY 10461


The NICE-AD study is a home-based clinical trial examining a treatment for Alzheimer’s Disease. We are interested in examining the effects of the device on cognition, mood, and neuroplasticity in patients with Alzheimer’s Disease. 

For this study, we will ask you (or the person you care for) to use a neurosimulation device at home, 30 minutes/day, 5 days/week, for 6 months. The neurostimulation device is worn like a headband and emits a painless current to the frontal lobe of the brain. The device is FDA-approved and has a good safety profile.

We will also ask you to take part in several appointments at Einstein. Two will take place before the 6-month intervention begins, and three will take place after the 6-month intervention. In some of these visits we will ask you to undergo an MRI, and in all of them we will ask you questions about your mood, health, and memory.

  • Must be community-dwelling male or female of age 60 and older
  • Must be mild-to moderate stage Alzheimer’s Disease
  • Must be able to speak and understand English sufficiently to undergo testing
  • Must be willing to complete an MRI
  • Must not have unstable psychiatric illness or stable for at least 3 months
  • Must not have history of head trauma, seizures, brain surgery, stroke or cancer affecting head, metal implants in the head or neck, compromised integrity or sensitivity of the skin at or near locations where electrodes will be placed
  • Must not be currently participating in another intervention study or using neurostimulation device
  • Must not have standard neuroimaging exclusions

Qualified Participants May Receive:

We provide free car service to and from the study (within 60mi) and compensate you (up to $460) for your time.

Available At:

Einstein-Montefiore Institute for Clinical and Translational Research
1225 Morris Park Avenue
Bronx, NY 10461
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If you or someone you care for is interested in participating and lives within 50 miles of the location shown, please complete the form below and click 'Submit'

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.