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Clinical Trial 4929

Los Alamitos, CA 90720

Study Summary:


Adults who stutter may feel frustration and anxiety when speaking in public. Now, researchers at Pharmacology Research Institute are seeking adults for a clinical research study to evaluate the safety, effectiveness and tolerability of an investigational medication, pagoclone for the treatment of people who stutter. Should pagoclone be found to be safe and effective in clinical trials, it may, in the future, offer people who stutter a medication to have an effect upon speech fluency.

“Stuttering can have a tremendous impact on a person’s life: their social functioning, their occupational achievement,” said Dr. Gerald A. Maguire, a lead investigator of the pagoclone stuttering study and Associate Professor of Clinical Psychiatry at the University of California, Irvine School of Medicine. “The treatment challenge is not only to improve fluency, but to reduce the individual’s anxiety and avoidances of certain feared speaking situations.”

Approximately 330 people who stutter will be enrolled to receive either pagoclone or a placebo (a sugar pill). The research study will require six office visits and four telephone check-in calls over an eight-month period. At the end of the eight-month treatment period, participants may choose to continue in an extension of the study in which all participants will receive the investigational medication, pagoclone, for approximately 12 months.

All study-related doctor’s visits, procedures and study medication will be provided at no cost. Participants may receive compensation for travel-related expenses.

To be eligible for the current pagoclone clinical trial, participants must be between the ages of 18 and 80 and have a history of stuttering prior to the age of eight. All adults must be English speaking with an eighth grade education level.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.