Clinical Trial 49939

Phoenix, AZ 85013


Summary:

The Ivy Brain Tumor Center at Barrow Neurological Institute, a nonprofit translational research program, is conducting a Phase 0/1b clinical trial to evaluate AZD1390 in patients with recurrent WHO grade IV glioma.

The goal of Phase 0  is to confirm that AZD1390 is capable of crossing the blood-brain barrier. Patients with positive results may advance to the 1b expansion phase which combines therapeutic dosing of AZD1390 with standard-of-care fractionated radiotherapy.

The expansion phase will examine progression-free survival and monitor safety and tolerability of AZD1390 in combination with radiation.

  • AZD1390 is a highly potent brain penetrant ATM (Ataxia telangiectasia mutant) kinase inhibitor that blocks the repair of DNA breaks caused by radiation treatment. 
  • AZD1390 is in early clinical development for use as a radiosensitizer in central nervous system malignancies.
  • Radiosensitizers  make tumor cells more vulnerable to radiation therapy.
  • You are 18 years or older.
  • You have had prior resection (surgical removal) of a diagnosed 2021 WHO grade IV glioma and followed standard therapy, including temozolomide and fractionated radiotherapy.
  • Your doctor has told you that your tumor has recurred (come back) or has progressed (grown or changed) and you require resection with radiation therapy as part of your post-surgical treatment plan.


Qualified Participants May Receive:

As part of a clinical trial at the Ivy Brain Tumor Center, the study drugs will be provided free of charge, however, the patient and/or their health plan/insurance company will be responsible for some or all of the costs of treating the tumor in the study, including any standard medical care such as surgical resection.


Available At:

St. Joseph's Hospital and Medical Center

Phoenix, AZ 85013
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Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.