
Click image to enlargeThe purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by assessing the reduction in signs and symptoms of PsA.
Criteria:--Have active Psoriatic Arthritis for at least 6 months
-- Have active plaque psoriasis
--Have an inadequate response and/or intolerance to anti-tumor necrosis factor alpha (TNF alpha) therapy, defined as presence of active PsA despite previous treatment with one prior anti-TNF alpha agent
--Does not have an inflammatory disease that might confound the evaluations of benefit of guselkumab therapy, including but not limited to RA, AS/nonradiographic AS, SLE, or Lyme disease.
--Has not received more than 1 prior anti-tumor necrosis factor (TNF) alpha agent (or biosimilars)
--Has never received Janus kinase (JAK) inhibitor including but not limited to tofacitinib, baricitinib, filgotinib, peficitinib, decernotinib, upadacitinib or any other investigational JAK inhibitor