Expired Study
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Clinical Trial 6908

Los Angeles, CA 90095

Study Summary:

This study is a multicenter, randomized double blind, sham controlled study to evaluate the safety and efficacy of H-coil deep transcranial magnetic stimulation (dTMS) as a treatment for patients with Major Depressive Disorder who have been previously unsuccessfully treated with antidepressant medications. Differing from traditional figure-8 coil, the H-coil is designed to stimulate deep brain regions related to motivation, reward, and pleasure. Preliminary studies have been conducted and seem to indicate that through stimulating certain brain areas with the H-coil, dTMS may have an antidepressant effect. The study population will consist of patients with major depressive disorder who have failed adequate medication treatment or shown significant intolerance to medications. The study duration is 18 weeks, with a 2 week period of weaning the patient off medication, followed by 4 weeks of 5 daily treatments and 12 weeks of biweekly treatments. Mood and mental state will be carefully monitored through standard psychological scales and rating during the drug taper-down and throughout treatment.

Qualified Participants Must:

• Be between the ages of 22-68
• Current depressive episode must be greater than 4 weeks but less than 5 years in duration
• Participants will NOT be eligible for this study if they have a history of schizophrenia, any psychotic disorder, PTSD, bipolar disorder, OCD, eating disorders or substance abuse, a history of panic disorder, social anxiety disorder or personality disorder, a history of any significant medical disease, a history of seizures. Other exclusions apply.

Qualified Participants May Receive:

Free evaluations by a Clinical Psychologist, a psychiatrist, and a 50% chance of receiving treatment (50% chance of receiving sham).

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.