Expired Study
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Clinical Trial 9380

Burbank, CA 91505

Study Summary:

The purpose of this study is to compare the analgesic efficacy and safety of ABT-652 administered twice daily (BID) to placebo in subjects with osteoarthritis (OA) of the knee.

Qualified Participants Must:

• Have a history of OA of the knee joint and meeting ACR Clinical and Radiographic criteria
• Have pain score as required by the protocol at screening and baseline
• Be willing to washout of analgesics and to follow treatment plan, visit schedules and study procedures
• Not have a history of sensitivity to histamine medications, acetaminophen (paracetamol), or non-steroidal anti-inflammatory drugs (NSAIDs)
• Not have active gastrointestinal (GI) disease, GI bleeding or GI ulceration, or history of GI bleeding or GI ulceration in the last 6 months
• Not have a history of major psychiatric disorders
• Not have a diagnosis of rheumatoid arthritis, autoimmune disorder, arthritis other than osteoarthritis involving the study joint, or other painful syndrome that could interfere with the assessment of pain at the study joint
• Not have any cardiac, respiratory, neurological or other medical condition or illness that is not well controlled with treatment

Qualified Participants May Receive:

Study drug, study-related medical exams, and study-related laboratory tests.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.