Clinical Trial 9470

Manahasset, NY 11030

Study Summary:

The SisSLE (Sisters of Women with Systemic Lupus Erythematosus) research study is looking for sisters: one with a diagnosis of systemic lupus erythematosus (SLE), an autoimmune disease and one (or more) who does not have lupus. Betty Diamond, MD, and Peter Gregersen, MD, designed the study to understand how individuals may progress to lupus. The pilot study will enroll 400 sisters over a 2-year period. Scientists will be able to identify auto-antibodies that play a role in lupus and study other changes in blood serum that may help predict disease. They will also be trying to figure out how auto-antibodies may interact with environmental factors to play a role in the development of lupus.

Lupus is nine times more common in women and the autoimmune disease can attack many different organs and tissues of the body. Lupus has a significant genetic component. The risk of developing SLE is .1 percent in the population and twice that in females. In first degree relatives the risk can be from 4 to 8 percent.

Supported by a grant from the NIH, the study hopes to lead to more effective treatments for lupus. Study participation is voluntary and confidential.

Qualified Participants Must:

• Be a women diagnosed with lupus up to and including 40 years of age, and one (or more) sisters or half-sisters who are currently between the ages of 10 and 45 with no signs of lupus
• Be willing to sign consent forms, submit blood samples and complete a phone questionnaire about their medical background and diagnosis.

Qualified Participants May Receive:

Participants will be given a $20 gift card for each blood draw.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.