Clinical Trial 11701

Las Vegas, NV 89144

Study Summary:

An open-label 52-week study to assess the long-term safety of nktr-118 in opioid-induced constipation (oic) in patients with non-cancer-related pain.

The study duration will be 54 to 58 weeks. The study will consist of 52 weeks of open-label treatment followed by a 2 week follow-up period.

Qualified Participants Must:

• Have constipation (less than or equal to 3 bowel movements per week) due to use of opiod pain medications (30 mg daily for at least 4 weeks)
• Be 18-85 years of age
• Not be taking opiod pain medications for cancer pain
• Meet other qualification that apply

Qualified Participants May Receive:

Study medical examinations, laboratory evaluations, study medication, time and travel compensation ofr completed study visits.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.