Summary:
Evaluating whether adding an investigational medication to an approved antidepressant therapy might give relief from the symptoms of major depressive disorder (MDD).
Participants will receive either the investigational medication or Seroquel XR or a placebo (an inactive substance) in addition to standard antidepressant therapy (ADT).
All study-related medications, office visits and examinations will be provided to you at no cost.
At the end of the study, you may be eligible to participate in a 52-week extension research study in which all participants will receive the investigational medication and an antidepressant medication. The study staff will discuss this with you at that time.
Qualified Participants Must:
• Be between 18 and 65 years of age
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Have been diagnosed with Major Depressive Disorder (MDD)
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Have been experiencing symptoms of depression for at least the past 2 months
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Have been taking at least one antidepressant medication as prescribed but it is not helping you enough
•
Additional criteria will be assessed by the study doctor