Clinical Trial 37934

Los Angeles, CA 90095


OPTIMUM is a research study for participants 60 and older with difficult to treat depression.

  •  Eligible participants are randomized to medication options:
    • STEP 1: (for 10 weeks) Adding aripiprazole or bupropion to currentantidepressant; or switch to bupropion
    • STEP 2: (for 10 weeks) Adding lithium to current antidepressant; or switch to nortriptyline

Protocol ID:IRB#16-001829 UCLA IRB Approved Approval Date: 6/6/2017 Through: 11/30/2017 Committee: Medical IRB 3

Qualified Participants Must:

• Be 60 years of age or older
• Be depressed
• Be taking an antidepressant, but not feeling better

Qualified Participants May Receive:

  • The study team will assess your side effects and mood for up to 12 months
  • Study psychiatrists will provide medication recommendations to your primary care physician

Available At:

University of California Los Angeles (UCLA)
760 Westwood Plaza
Division of Geriatric Psychiatry - Semel Institute for Neuroscience & Human Behavior
Los Angeles, CA 90095
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If you or someone you care for is interested in participating and lives within 50 miles of the location shown, please complete the form below and click 'Submit'

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.