Clinical Trial 37934

Los Angeles, CA 90095


OPTIMUM is a research study for participants 60 and older with difficult to treat depression.

  •  Eligible participants are randomized to medication options:
    • STEP 1: (for 10 weeks) Adding aripiprazole or bupropion to currentantidepressant; or switch to bupropion
    • STEP 2: (for 10 weeks) Adding lithium to current antidepressant; or switch to nortriptyline

Protocol ID:IRB#16-001829 UCLA IRB Approved Approval Date: 6/6/2017 Through: 11/30/2017 Committee: Medical IRB 3

Qualified Participants Must:

• Be 60 years of age or older
• Be depressed
• Be taking an antidepressant, but not feeling better

Qualified Participants May Receive:

  • The study team will assess your side effects and mood for up to 12 months
  • Study psychiatrists will provide medication recommendations to your primary care physician

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.