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Clinical Trial 39819

Boston, MA 02115

Study Summary:

This study is an 8-week outpatient study evaluating whether aspirin can help treat depression. We want to see if some people will improve more from taking aspirin along with their depression treatments. Aspirin is an over-the-counter medication that is used for a variety of conditions, however it is not currently used to treat major depression.

The study requires 4 visits over the course of 8 weeks to Brigham and Women’s Hospital. Each visit lasts between approximately 45 minutes to 1.5 hours. The study visits will involve the study team asking about depression and mood. We will also be taking blood and urine samples. People who are eligible for this study will receive psychiatric evaluations and study medications free of charge. Those who complete the study will receive a total of $200. Participation is entirely voluntary.

Qualified Participants Must:

• Be 18-55 years old
• Have a current diagnosis of major depressive disorder
• Have no major neurologic or autoimmune condition
• Not be taking any anti-inflammatory or blood-thinning medications

Qualified Participants May Receive:

Psychiatric evaluations and study medications free of charge, as well as $200 upon completion of the study.

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Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.