Clinical Trial 43166

Los Angeles, CA 90024


PCORI has identified treatment-resistant depression as an important research topic. Patients, clinicians, and others want to learn: For patients whose depression has not gotten better after using two types of antidepressants, is it better to add another treatment or switch to a new one?

The research team is assigning patients by chance to receive one of three treatments that the Food and Drug Administration has approved for treatment-resistant depression.

  • For one group of patients, doctors are adding a treatment called repetitive transcranial magnetic stimulation (rTMS) to the antidepressant medicine each patient currently takes. During rTMS, a magnet above a patient’s head painlessly stimulates brain cells to improve depression symptoms. Patients in this treatment group are receiving rTMS five times a week for the first five weeks and twice a week for the next three weeks.
  • For the second group of patients, doctors are adding a second medicine, aripiprazole, to each patient’s current medicine.
  • For the third group of patients, doctors are switching from their current antidepressant medicines to a different medicine, venlafaxine.


  • Ages 18-80
  • Male or Female
  • Current episode of depression of at least 12 weeks duration
  • Meet criteria for Treatment Resistant Depression (TRD) during the current major depressive episode
  • Have had an inadequate response to at least 2 antidepressants
  • Are currently on an antidepressant for at least 8 weeks
  • Are currently on a stable dose of an antidepressant for at least 4 weeks and
  • Have experienced less than 50% improvement to the current antidepressant

Qualified Participants May Receive:

$100 compensation per completed visit

Available At:

Cal Neuro Research Group
10850 Wilshire Blvd., Suite 1260
Los Angeles, CA 90024
View Clinic Location


If you or someone you care for is interested in participating and lives within 50 miles of the location shown, please complete the form below and click 'Submit'

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.