Clinical Trial 9406

Burbank, CA 91505

Study Summary:

The purpose of this study is to determine the efficacy, safety, and tolerability of different doses of JNJ-27018966 compared with placebo in the treatment of patients with irritable bowel syndrome with diarrhea (IBS-d).

Qualified Participants Must:

• Have a diagnosis of IBS by Rome III criteria with a subtype of diarrhea
• Have an average daily pain score of ≥3.0 on a 0- to 10-point scale over the past week
• Have a weekly mean stool consistency score (BSS) of ≥5.5 over the past week
• If female, be postmenopausal, defined as amenorrhea for at least 2 years, at pre-screening
• If female, be surgically sterile (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy)
• If female, be abstinent, or if sexually active, be practicing an effective method of birth control

Qualified Participants May Receive:

Study related care, diagnostic tests, and study medication at no cost. Payment for time and travel to the study center may be provided.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.