Summary:
The purpose of the study is to learn why some vaccines such as the yellow fever vaccine provide durable protection while the influenza vaccine only protects for some months. We will use the knowledge gained from answering this question to make or improve vaccines, so they generate long-lasting immune responses. To learn what are the factors that predominantly dictate the durability of response to a vaccine, we will study the immune response to the yellow fever vaccine, and the seasonal influenza vaccine, in the blood (where antibodies are), in the lymph nodes (where immune cells that make antibodies are present), and in the bone marrow (where long-lived cells that secrete antibodies are found).
Qualified Participants Must:
• Be between the ages of 18 and 50
• Not have a history of allergy or serious adverse reaction to a vaccine or vaccine products
• Not have a history of a medical condition resulting in impaired immunity
• Allow clinicians to take fine needle aspirates or biopsies of lymph nodes at a maximum of two separate visits
• Donate a small amount of bone marrow by needle aspiration at a maximum of three separate visits
Qualified Participants May Receive:
$775 to $2600 in total, if all study visits are completed:
- $75 for each completed study visit, including the screening, and follow up visits.
- $100 for the vaccination visit
- $15 for the phone calls after each procedure
- $350 for each visit that involves lymph node sampling or the bone marrow aspiration