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The
purpose of this trial is to see how your immune system (your body’s natural
defense that fights off germs and keeps you healthy) reacts to an
investigational vaccine against Sudan virus disease.
In
humans, Sudan Ebolavirus (SUDV) is responsible for causing Sudan Virus Disease
(SVD), formerly known as Ebola hemorrhagic fever. It spreads through
human-to-human transmission, with infection resulting from direct contact with
blood, secretions, organs, or other bodily fluids of infected people, and
indirect contact with contaminated environments. The average case fatality rate
of SVD is around 50%.
As there are
currently no approved vaccines or therapeutics to treat individuals infected
with SUDV, a vaccine with rapid and durable protective immunity would be
desirable for populations in areas of the world where outbreaks occur
sporadically